Exploring the Structure and Biochemistry of Oxidation-Mediated Inhibitation of the Peptidyl-Prolyl Isomerase PIN1
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چکیده
.................................................................................................................. ii Co-Authorship Statement....................................................................................... iii Acknowledgments.................................................................................................. iv Table of
منابع مشابه
Proteasomal degradation of human peptidyl prolyl isomerase pin1-pointing phospho Bcl2 toward dephosphorylation.
Microtubule inhibitor-induced Bcl2 phosphorylation is detrimental to its antiapoptotic function. Phosphorylation of Bcl2 predominantly occurs on two serine residues (70 and 87) in cells arrested at G2-M phase by microtubule disarraying agents. Phospho Bcl2 can associate with a cis-trans peptidyl prolyl isomerase, Pin1. Pin1 and its homologues are known to target the proline residue carboxyl ter...
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Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase (PPIase) that has the potential to add an additional level of regulation within protein kinase mediated signaling pathways. Furthermore, there is a mounting body of evidence implicating Pin1 in the emergence of pathological phenotypes in neurodegeneration and cancer through the isomerization of a wide variety of substrates at peptidy...
متن کاملRole of the peptidyl-prolyl cis/trans isomerase Pin1 in the ubiquitin proteasome system (UPS)
Wesentliche Teile dieser Arbeit sind in folgenden Publikationen veröffentlicht: Prolyl isomerase Pin1 acts as a switch to control the degree of substrate 14 3 Aim of this study 16 4 Results 17 4.1 The peptidyl-prolyl cis/trans isomerase Ess1 is an essential new player of the OLE pathway 17 4.1.1 Ess1 is a essential new player in the OLE pathway and functionally directly linked to Ole1 18 4.1.2 ...
متن کاملThe peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55.
Failure of cytokinesis results in tetraploidy and can increase the genomic instability frequently observed in cancer. The peptidyl-prolyl isomerase Pin1, which is deregulated in many tumors, regulates several processes, including cell cycle progression. Here, we show a novel role for Pin1 in cytokinesis. Pin1 knockout mouse embryonic fibroblasts show a cytokinesis delay, and depletion of Pin1 f...
متن کاملThe peptidyl-prolyl isomerase Pin1 regulates granulocyte-macrophage colony-stimulating factor mRNA stability in T lymphocytes.
Cytokine production is associated with both the normal and pathologic inflammatory response to injury. Previous studies have shown that the immunosuppressants cyclosporin A or FK506, which interact with the peptidyl-propyl isomerases cyclophilin A and FK506-binding protein (FKBP12), respectively, block cytokine expression. A third member of the peptidyl-propyl isomerase family, Pin1 is expresse...
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